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Clinical features and nigrostriatal dysfunction in patients with combined postural and resting tremors

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Affiliated Author(s)
유수연
Alternative Author(s)
You, Soo Yeoun
Journal Title
Parkinsonism & Related Disorders
ISSN
1353-8020
Issued Date
2013
Keyword
Postural tremorResting tremorEssential tremorParkinson’s disease[18F] FP-CIT PET
Abstract
Background

The characteristics of clinical features and nigrostriatal dopaminergic dysfunction in patients with combined postural and resting tremors have been less clearly reported.

Methods

The present study examined 43 patients with a visible persistent bilateral postural tremor and a unilateral/bilateral resting tremor involving the hands and forearms. The patients had experienced tremors for more than 3 years, with no evidence of Parkinson's disease or other parkinsonian disorders. Visual and quantitative analyses of [18F] N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (FP-CIT) PET in 36 patients were performed. Seventeen age-matched normal controls were also studied.

Results

On visual analysis, 28 patients (78%) showed normal [18F] FP-CIT uptake and eight (22%) showed significantly reduced uptake, suggesting nigrostriatal dopaminergic neuronal degeneration. The reduced [18F] FP-CIT uptake was significantly associated with earlier age-at-onset of tremor and asymmetric presentation of resting tremor. On quantitative analysis, there were statistically significant differences in the [18F] FP-CIT uptake ratio in the posterior putamen between patients with reduced uptake (2.37 ± 1.83) and patients with normal uptake (6.39 ± 1.35) (P < 0.001). However, posterior putamen uptake levels in patients with normal [18F] FP-CIT uptake on visual analysis were similar to those in normal controls (7.22 ± 1.29) (P = 0.291).

Conclusion

The nigrostriatal dopaminergic dysfunction in patients with combined postural and resting tremors may be associated with earlier age-at-onset of tremor and asymmetric pattern of resting tremor, which might help to correctly diagnose patients with mixed tremors.

Keywords
Postural tremor;
Resting tremor;
Essential tremor;
Parkinson's disease;
[18F] FP-CIT PET
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
Sooyeoun You et al. (2013). Clinical features and nigrostriatal dysfunction in patients with combined postural and resting tremors. Parkinsonism & Related Disorders, 19(12), 1118–1122. doi: 10.1016/j.parkreldis.2013.08.002
Type
Article
ISSN
1353-8020
DOI
10.1016/j.parkreldis.2013.08.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33638
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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