Immunohistochemical analysis for histopathological subtypes in pediatric medulloblastomas
- Affiliated Author(s)
- 손은익; 김엘; 김동원; 임만빈; 강유나; 이상숙; 권건영; 김상표; 서성일; 권택규; 이중정
- Alternative Author(s)
- Son, Eun Ik; Kim, El; Kim, Dong Won; Yim, Man Bin; Kang, Yu Na; Lee, Sang Sook; Kwon, Kun Young; Kim, Sang Pyo; Suh, Seong Il; Kwon, Taeg Kyu; Lee, Jung Jeung
- Journal Title
- Pathology International
- ISSN
- 1320-5463
- Issued Date
- 2003
- Keyword
- anaplasia; histopathology; immunohistochemistry; medulloblastoma; pediatric; subtype
- Abstract
- Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non-anaplastic, four diffuse/anaplastic, three nodular/non-anaplastic and one nodular/anaplastic subtypes, were studied. In the present report, we investigate the expression of neural cell adhesion molecule (NCAM), nerve growth factor receptor (NGFR), neurofilament (NF), synaptophysin (SYN), glial fibrillary acidic protein (GFAP), S100, Bcl-2, and Ki-67 by using the immunohistochemistry against specific antibodies. This study showed that NGFR, NF, GFAP and S100 were not detected in anaplastic subtypes of medulloblastomas (0/5), while non-anaplastic subtypes were mainly expressed within the nodules. All 17 tumors were reactive for NCAM, SYN and Bcl-2. In addition, Ki-67 labeling indices for anaplastic subtypes (39.0 +/- 7.42%) were significantly higher than that of non-anaplastic medulloblastomas (11.4 +/- 8.04%; P < 0.0001). These results suggest that immunohistochemical markers are a useful adjunct in characterizing subtypes of pediatric medulloblastomas.
Key words: anaplasia, histopathology, immunohistochemistry,
medulloblastoma, pediatric, subtype.
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