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Determinants of non-compliance with lipid-lowering therapy in hyperlipidemic patients

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Affiliated Author(s)
김대현
Alternative Author(s)
Kim, Dae Hyun
Journal Title
Pharmacoepidemiology and Drug Safety
ISSN
1053-8569
Issued Date
2002
Keyword
lipid-lowering drughyperlipidemiacompliance
Abstract
PURPOSE:
In order to assess the determinants of non-compliance with a lipid-lowering therapy, a prospective study of the hyperlipidemic Korean subjects was carried out.

METHODS:
A total of 1019 patients was observed by 46 family physicians for the period of 1 year from January 1999 to January 2000. To ascertain the compliance associated with a lipid lowering drug (Simvastatin), we regularly followed up the hyperlipidemic patients at intervals of 4, 12 and 24 weeks. The criterion for evaluating compliance is to measure clinic attendance. Using a structured questionnaire, patients and physicians were asked about risk factors for the compliance.

RESULTS:
During the first 24 weeks of treatment, the lipid-lowering medication was continued by 52.3% and discontinued by 19.7%. The remaining 28% dropped out. Patient-related factors for non-compliance were young age, current smoker, lack of low fat diet and exercise, new user, no concomitant medication, and occurrence of adverse reactions. Physician-related factors for non-compliance were low patients' satisfaction with the physician, small number of hyperlipidemic patients per month and working in a relatively small hospital.

CONCLUSIONS:
Compliance with the lipid-lowering therapy was relatively low and several factors for non-compliance were detected.
key words—lipid-lowering drug; hyperlipidemia; compliance
Department
Dept. of Family Medicine (가정의학)
Publisher
School of Medicine
Citation
Young Sik Kim et al. (2002). Determinants of non-compliance with lipid-lowering therapy in hyperlipidemic patients. Pharmacoepidemiology and Drug Safety, 11(7), 593–600. doi: 10.1002/pds.730
Type
Article
ISSN
1053-8569
DOI
10.1002/pds.730
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33664
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Family Medicine (가정의학)
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