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Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates

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Affiliated Author(s)
서성일이형김인수이성용
Alternative Author(s)
Suh, Seong IlLee, HyungKim, In SooLee, Seong Ryong
Journal Title
Phytotherapy Research
ISSN
0951-418X
Issued Date
2007
Keyword
lipid peroxidationGastrodia elataantioxidanthydroxybenzyl alcohol
Abstract
Gastrodia elata (GE) Blume, a traditional herbal agent, has been used mainly in anticonvulsive treatment in Asia. Recently, extracts of GE were evaluated for their potential as neuroprotectives and antioxidants. This study was designed to examine the antioxidant effect of the ether fraction of the methanol extract (EFME) of GE along with its major constituents vanillin, vanillyl alcohol, hydroxybenzaldehyde and hydroxybenzyl alcohol. In experiment 1, gerbils were treated with EFME of GE at a dosage of 500 mg/kg/day for 2 weeks. Oxidative stress was induced with H(2)O(2) or ferrous ion, and lipid peroxidation was measured. In experiment 2, oxidative stress was induced with various concentrations of H(2)O(2) or ferrous ammonium sulfate, and lipid peroxidation was measured. To compare the antioxidant potency, the inhibitory concentration 50% (IC(50)) was determined. EFME of GE reduced auto-peroxidation and H(2)O(2)-induced lipid peroxidation. However, it did not significantly reduce ferrous ammonium sulfate-induced lipid peroxidation. The order of antioxidation potency was as follows: hydroxybenzyl alcohol > vanillyl alcohol > vanillin > hydroxybenzaldehyde. In the case of hydroxybenzaldehyde, its antioxidant effect was more potent than that of melatonin. The excellent antioxidant effects of GE and its main constituents may have potential in the treatment of lipid peroxidation-associated neurological disease.
Keywords: lipid peroxidation; Gastrodia elata; antioxidant; hydroxybenzyl alcohol.
Department
Dept. of Microbiology (미생물학)
Dept. of Neurology (신경과학)
Dept. of Neurosurgery (신경외과학)
Dept. of Pharmacology (약리학)
Publisher
School of Medicine
Citation
Tae-Young Jung et al. (2007). Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates. Phytotherapy Research, 21(10), 960–964. doi: 10.1002/ptr.2193
Type
Article
ISSN
0951-418X
DOI
10.1002/ptr.2193
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33671
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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