계명대학교 의학도서관 Repository

The Effect of Baicalein on Hippocampal Neuronal Damage and Metalloproteinase Activity Following Transient Global Cerebral Ischaemia

Metadata Downloads
Affiliated Author(s)
이성용
Alternative Author(s)
Lee, Seong Ryong
Journal Title
Phytotherapy Research
ISSN
0951-418X
Issued Date
2012
Keyword
baicaleinglobal ischaemiaScutellaria baicalensismatrix metalloproteinasehippocampus
Abstract
Baicalein, a flavonoid derived from Scutellaria baicalensis Georgi, is known to protect neural tissue from damage. Several studies have found that baicalein reduces brain infarction following focal brain ischaemia. However, there are few reports on the protective effects of baicalein following global brain ischaemia. Therefore, the current study was designed to address the effects of baicalein on neuronal damage and matrix metalloproteinase (MMP; gelatinase) activity in the hippocampus after transient global ischaemia. C57BL/6 mice were subjected to transient global brain ischaemia for 20 min and sacrificed 72 h after ischaemic insult. Baicalein (200 mg/kg, once daily, as a suspension in 0.5% carboxymethylcellulose) or an equal volume of vehicle was orally administered to the mice from 7 days prior to the ischaemic insult until sacrifice. After global ischaemia neuronal damage was significant in CA1 and CA2 pyramidal cell layers. In baicalein-treated mice, neuronal damage from the ischaemic insult was significantly less than that in vehicle-treated mice. Baicalein administration also inhibited MMP-9 activity in the hippocampus. These data demonstrate that baicalein reduces hippocampal neuronal damage after transient global ischaemia. Besides its possible protective mechanisms, the protective role of baicalein against global ischaemia may operate, at least in part, through the inhibition of MMP-9 activity.
Keywords:

baicalein;
global ischaemia;
Scutellaria baicalensis;
matrix metalloproteinase;
hippocampus
Department
Dept. of Pharmacology (약리학)
Brain Research Institute (뇌연구소)
Publisher
School of Medicine
Citation
Jung-Hyun Lee and Seong-Ryong Lee. (2012). The Effect of Baicalein on Hippocampal Neuronal Damage and Metalloproteinase Activity Following Transient Global Cerebral Ischaemia. Phytotherapy Research, 26(11), 1614–1619. doi: 10.1002/ptr.4644
Type
Article
ISSN
0951-418X
DOI
10.1002/ptr.4644
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33672
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.