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dc.contributor.authorBo Ram Seo-
dc.contributor.authorKyoung-jin Min-
dc.contributor.authorShin Kim-
dc.contributor.authorJong-Wook Park-
dc.contributor.authorWon-Kyun Park-
dc.contributor.authorTae-Jin Lee-
dc.contributor.authorTaeg Kyu Kwon-
dc.date.accessioned2018-08-08T16:33:57Z-
dc.date.available2018-08-08T16:33:57Z-
dc.date.issued2013-
dc.identifier.citationBiochimie, Vol.95(4) : 858-865, 2013-
dc.identifier.issn0300-9084-
dc.identifier.otheroak-aaa-05104-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/33705-
dc.description.abstractAnisomycin is known to inhibit protein synthesis and induce ribotoxic stress. In this study, we investigated whether anisomycin treatment could modulate TRAIL-mediated apoptosis in human renal carcinoma Caki cells. We found that anisomycin treatment (10–15 nM) alone had no effect on the level of apoptosis, but a combination treatment of anisomycin and TRAIL significantly increased the level of apoptosis in human renal carcinoma (Caki, ACHN and A498), human glioma (U251MG), and human breast carcinoma (MDA-MB-361 and MCF7) cells. Anisomycin treatment led to the down-regulation of Bcl-2 expression at the transcriptional level, and the over-expression of Bcl-2 inhibited the apoptosis induced by the combination treatment of anisomycin and TRAIL. Furthermore, anisomycin treatment resulted in the down-regulation of c-FLIP(L) and Mcl-1 at the post-transcriptional level, and the over-expression of c-FLIP(L) and Mcl-1 blocked the induction of apoptosis caused by the combination treatment of anisomycin with TRAIL. In contrast, anisomycin treatment had no effect on the levels of TRAIL-mediated apoptosis in mouse kidney cells (TMCK-1) or normal human skin fibroblasts (HSF). Cumulatively, our study demonstrates that anisomycin treatment enhances TRAIL-mediated apoptosis through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1 at the transcriptional or post-transcriptional level.-
dc.description.statementofresponsibilityrestriction-
dc.publisherSchool of Medicine-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.titleAnisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1-
dc.typeArticle-
dc.contributor.localauthor김신-
dc.contributor.localauthor박종욱-
dc.contributor.localauthor권택규-
dc.contributor.localauthor박원균-
dc.contributor.alternativelocalauthorKim, Shin-
dc.contributor.alternativelocalauthorPark, Jong Wook-
dc.contributor.alternativelocalauthorKwon, Taeg Kyu-
dc.contributor.alternativelocalauthorPark, Won Kyun-
dc.contributor.departmentDept. of Immunology (면역학)-
dc.contributor.departmentDept. of Medical Education (의학교육학)-
dc.citation.volume95-
dc.citation.number4-
dc.citation.startpage858-
dc.citation.titleBiochimie-
dc.citation.endpage865-
dc.identifier.doi10.1016/j.biochi.2012.12.002-
dc.identifier.urlhttp://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0300908412004786?via%3Dihub-


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