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Unusual chromosomal features in a child with gradual disappearance of right ulna(mono ostolic oseolysis)

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Affiliated Author(s)
이인환장성익
Alternative Author(s)
Lee, In HwanChang, Sung Ik
Journal Title
Journal of Genetic Medicine
ISSN
1226-1769
Issued Date
1997
Keyword
humanosteolysiskaryotype
Abstract
Most cirrhotic patients with hepatocellular carcinoma (HCC) are not candidates for resection. Transarterial chemoembolization (TACE) may ablate a significant portion of the tumor but has a high rate of recurrence. Cryosurgery may permit successful ablation of hepatic tumors but can be complicated by postoperative hemorrhage and is also associated with a significant risk of recurrence. The combination of the two techniques might be beneficial. We evaluated in a prospective study the safety and efficacy of this combination in cirrhotic patients with unresectable HCC. Fifteen patients were included in this study. All but one patient underwent one or several sessions of TACE before cryosurgery. Cryoablation was successfully performed in each patient. The patient who did not undergo preoperative TACE required reoperation for hemorrhage. Another patient with Child-Pugh class B cirrhosis died postoperatively of hepatic and multiorgan failure. At a mean follow-up of 2.5 years, three patients had recurrence of disease, and 13 of 15 patients were alive with the longest survival time being 5 years. The actuarial survival rate at 5 years was 79%. Cryosurgery after TACE is feasible in cirrhotic livers with HCC and can increase the cure rate in large tumors. TACE may reduce the risk of hemorrhage after cryosurgery but can increase the risk of hepatic failure in patients with poor hepatic function.
Department
Dept. of Anatomy (해부학)
Publisher
School of Medicine
Citation
Journal of Genetic Medicine, Vol.1(1) : 11-16, 1997
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33782
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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