Risk Factors for Acute Hepatitis A Infection in Korea in 2007 and 2009: A Case-Control Study
- Affiliated Author(s)
- 황재석
- Alternative Author(s)
- Hwang, Jae Seok
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Issued Date
- 2013
- Keyword
- Case-Control Studies; Hepatitis A; Korea; Risk Factors
- Abstract
- This study aimed to identify the risk factors associated with acute hepatitis A virus (HAV)
infection in the Korean population. Participants were recruited from five referral hospitals
across the country in 2007 and from 11 hospitals in 2009. Patients with positive anti-HAV
IgM antibody tests became the case group, while patients treated for non-contagious
diseases at the same hospitals were recruited as controls. A total of 222 and 548 casecontrol
pairs were studied in the 2007 and 2009 surveys, respectively. Data from the
surveys were analyzed jointly. In a multivariate analysis, sharing the household with HAVinfected
family members (OR, 6.32; 95% CI, 1.4-29.6), contact with other HAV-infected
individuals (OR, 4.73; 95% CI, 2.4-9.4), overseas travel in 2007 (OR, 19.93; 95% CI, 2.3-
174.4), consumption of raw shellfish (OR, 2.51; 95% CI, 1.8-3.5), drinking bottled water
(OR, 1.64; 95% CI, 1.3-8.4), and occupation that involve handling food (OR, 3.30; 95%
CI, 1.3-8.4) increased the risk of HAV infection. Avoiding contact with HAV-infected
individuals and avoiding raw foods eating could help minimize the risk of hepatitis A
infection. Immunization must be beneficial to individuals who handle food ingredients
occupationally or travel overseas to HAV-endemic areas.
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