Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma

Abstract

Loss of heterozygosity (LOH) has been established as an important genetic mech-anism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas have been report-ed. The purpose of this study was to investigate the significance of LOH in the patho-genesis of sporadic keratoacanthomas developed in 10 Korean patients. The pre-sents of LOH at 7 microsatellite markers (D2S286, D3S1317, D5S346, D9S160, D9S171, D10S185, and D17S261) were evaluated in sporadic keratoacanthomas. LOH was found in only 1 of 10 cases at D10S185. The low frequency of LOH detect-ed in this study suggests that LOH may not be significant in the induction of sporadic keratoacanthomas.