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Biweekly Irinotecan and Cisplatin as Second-line Chemotherapy in Pretreated Patients with Advanced Gastric Cancer: A Multicenter Phase II Study

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Affiliated Author(s)
송홍석권기영도영록박건욱
Alternative Author(s)
Song, Hong SukKwon, Ki YoungDo, Young RokPark, Keon Uk
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934
Issued Date
2005
Keyword
irinotecanCisplatinDrug TherapyStomach Neopla는
Abstract
The current phase II study was conducted to evaluate the response rate and safety
of a combination regimen of biweekly irinotecan plus cisplatin in pretreated patients
with advanced gastric cancer. Patients with previously treated metastatic or recurrent
gastric cancer received intravenous irinotecan 70 mg/m2 and cisplatin 30
mg/m2 on day 1 and 15 every 4-week cycle. Thirty-two patients were enrolled in the
current study. Of these, 31 patients were assessable for efficacy and all for toxicity.
No complete response and 5 partial responses were confirmed, giving an overall
response rate of 15.6% (95% CI; 2.3-28.9%). The median time to progression and
median overall survival for all patients was 113 days and 184 days, respectively.
Grade 3/4 neutropenia occurred in 6 patients (18.8%), yet no febrile neutropenia
was observed. In addition, grade 3 anorexia was observed in 4 patients (12.5%)
and grade 3 diarrhea occurred in 2 patients (6.2%). The combination chemotherapy
of biweekly irinotecan and cisplatin was found to be moderately effective and well
tolerated in pretreated patients with advanced gastric cancer. Accordingly, this regimen
can be regarded as an important second-line treatment option for advanced
gastric cancer.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Jin Ho Baek et al. (2005). Biweekly Irinotecan and Cisplatin as Second-line Chemotherapy in Pretreated Patients with Advanced Gastric Cancer: A Multicenter Phase II Study. Journal of Korean Medical Science, 20(6), 966–970. doi: 10.3346/jkms.2005.20.6.966
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2005.20.6.966
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33798
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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