Indexes of Suspicion of Typical Cow’s Milk Protein-Induced Enterocolitis
- Affiliated Author(s)
- 황진복; 강유나; 김상표; 서성일
- Alternative Author(s)
- Hwang, Jin Bok; Kang, Yu Na; Kim, Sang Pyo; Suh, Seong Il
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Issued Date
- 2007
- Keyword
- Cow’s Milk Protein-Induced Enterocolitis; Index of Suspicion
- Abstract
- This study was performed to identify clinical factors that facilitate the diagnosis of
typical cow’s milk protein-induced enterocolitis (CMPIE). Data from 142 consecutive
patients (aged 15 to 45 days, cow’s milk formula- or cow’s milk and breast
milk mixed-fed) admitted due to vomiting and/or diarrhea were retrospectively analyzed.
These 142 subjects were divided into three groups: the CMPIE, infection,
and non-infection group. Each group was composed of 16 (11.3%), 102 (71.8%),
and 24 (16.9%) patients, respectively. On admission, poor weight gain (p=0.003),
hypoalbuminemia (p=0.035), peripheral leukocytosis (p=0.012), and metabolic
acidosis (p=0.015) were found to be more significant in the CMPIE group than
those in other two groups. In CMPIE, serum albumin levels decreased from 3.3
±0.9 g/dL on admission to 2.6±0.3 g/dL during admission (p<0.05), and methemoglobinemia
was observed in 3 patients (18.8%) (p=0.012). Multiple logistic regression
analysis showed that the independent predictors of CMPIE versus the
infection group were failure to gain weight (OR, 10.75 [95% CI, 1.53-66.12]) (p=
0.014) and hypoalbuminemia (OR, 9.53 [95% CI, 1.62-49.01]) (p=0.010). The
early recognition of indexes of suspicion for CMPIE may be of help in the diagnosis
and treatment of this disorder.
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