Infliximab Partially Alleviates the Bite Force Reduction in a Mouse Model of Temporomandibular Joint Pain
- Affiliated Author(s)
- 정성원; 김상현; 손창남; 조호찬; 정혜라; 백원기; 홍지희
- Alternative Author(s)
- Jung, Sung Won; Kim, Sang Hyon; Son, Chang Nam; Cho, Ho Chan; Jung, Hye Ra; Baek, Won Ki; Hong, Ji Hee
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Issued Date
- 2015
- Keyword
- Bite Force; Infliximab; Temporomandibular Joint Pain
- Abstract
- TTemporomandibular joint (TMJ) disorder is clinically important because of its prevalence,
chronicity, and therapy-refractoriness of the pain. In this study, we investigated the effect
of infliximab in a mouse model of TMJ pain using a specially-engineered transducer for
evaluating the changes in bite force (BF). The mice were randomly divided into three
groups (7 mice per group): the control group, the complete Freund’s adjuvant (CFA) group,
and the infliximab group. BF was measured at day 0 (baseline BF). After measuring the
baseline BF, CFA or incomplete Freund’s adjuvant was injected into both TMJs and then the
changes in BF were measured at days 1, 3, 5, 7, 9, and 13 after the TMJ injection. For
measuring the BF, we used a custom-built BF transducer. Control, CFA, and infliximab
groups showed similar baseline BF at day 0. From day 1, a significant reduction in BF was
observed in the CFA group, and this reduction in BF was statistically significant compared
to that in the control group (P < 0.05). This reduction in BF was maintained until day 7,
and BF started to recover gradually from day 9. In the infliximab group also, the reduction
in BF was observed on day 1, and this reduction was maintained until day 7. However, the
degree of reduction in BF was less remarkable compared to that in the CFA group. The
reduction in BF caused by injection of CFA into the TMJ could be partially alleviated by the
injection of anti-tumor necrosis factor alpha, infliximab.
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