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Change of Fecal Flora and Effectiveness of the Short-term VSL#3 Probiotic Treatment in Patients With Functional Constipation

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Affiliated Author(s)
박경식
Alternative Author(s)
Park, Kyung Sik
Journal Title
Journal of Neurogastroenterology and Motility
ISSN
2093-0879
Issued Date
2015
Keyword
ConstipationMicrobiomeProbiotics
Abstract
Background/Aims:
We investigated gut flora characteristics in patients with functional constipation (FC) and influences of short-term treatment
with VSL#3 probiotic on flora and symptom improvement.
Methods:
Thirty patients fulfilling Rome III criteria for FC and 30 controls were enrolled. Fecal samples were obtained before and after
VSL#3 intake (one sachet twice daily for 2 weeks) and flora were examined by quantitative real-time polymerase chain reaction
(qRT-PCR). Symptom changes were also investigated.
Results:
The fold differences in Bifidobacterium and Bacteroides species were significantly lower in feces from FC, compared to in controls
(P = 0.030 and P = 0.021). After taking VSL#3, the fold differences in Lactobacillus, Bifidobacterium and Bacteroides
species increased in controls (P = 0.022, P = 0.018, and P = 0.076), but not in FC. Mean Bristol scores and complete spontaneous
bowel movements (CSBMs)/week increased significantly in FC after ingesting VSL#3 (both P < 0.001). Relief of subjective
CSBM frequency, stool consistency and abdominal bloating were reported in 70%, 60%, and 47% of patients. After VSL#3 cessation,
44.4% of patients with symptom improvement experienced constipation recurrence mostly within one month.
Conclusions:
Bifidobacterium and Bacteroides species might be quantitatively altered in FC. A short-term VSL#3 treatment can improve clinical symptoms
of FC. Further studies are needed to investigate VSL#3’s additional effects beyond altering gut flora to allevate constipation.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Seong-Eun Kim et al. (2015). Change of Fecal Flora and Effectiveness of the Short-term VSL#3 Probiotic Treatment in Patients With Functional Constipation. Journal of Neurogastroenterology and Motility, 21(1), 111–120. doi: 10.5056/jnm14048
Type
Article
ISSN
2093-0879
DOI
10.5056/jnm14048
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33832
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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