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Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation

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Affiliated Author(s)
황일선
Alternative Author(s)
Hwang, Il Seon
Journal Title
Journal of Thrombosis and Thrombolysis
ISSN
0929-5305
Issued Date
2011
Keyword
Acute coronary syndromeIntravascular ultrasoundPlaque instabilityTissue factor
Abstract
It remains uncertain why some plaque ruptures trigger acute coronary syndrome (ACS), whereas others do not. We investigated the anatomic features and tissue factor (TF) expression at the sites of plaque rupture in 42 patients presenting with ACS (n = 23) or stable angina (n = 19). Intravascular ultrasound examination was performed before directional coronary atherectomy. Specimens were stained with antibodies against TF, CD68 positive phagocytic cells, and smooth muscle cells; and intravascular ultrasound and immunohistochemistry results were compared. Baseline demographic and clinical characteristics, as well as vessel and lumen sizes at both reference and lesion sites, were comparable in the two groups. However, the remodeling index and plaque burden at lesion sites were significantly greater in the ACS than in the stable angina group. The TF-immunopositive areas were significantly greater in the ACS than in the stable angina group (0.07%; IQR [0.02–0.16%] vs. 0.02%; IQR [0.01–0.05%], P = 0.022), whereas the proportions of CD68-positive and smooth muscle cell areas were similar. There was a significant correlation between areas positive for TF and those positive for CD68 (r = 0.83, P < 0.001). In conclusion, ruptured plaques in patients with ACS show stronger TF expression, a greater plaque burden, and a higher remodeling index than do plaques in those with stable angina, suggesting that both lesion morphology and local thrombogenicity are related to clinical symptoms after plaque rupture.
Department
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Cheol Whan Lee et al. (2011). Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation. Journal of Thrombosis and Thrombolysis, 32(2), 150–157. doi: 10.1007/s11239-011-0585-6
Type
Article
ISSN
0929-5305
DOI
10.1007/s11239-011-0585-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33888
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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