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A Reexamination of the Role of GABA in the Mammalian Suprachiasmatic Nucleus

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Affiliated Author(s)
박원균
Alternative Author(s)
Park, Won Kyun
Journal Title
Journal of Biological Rhythms
ISSN
0748-7304
Issued Date
1999
Keyword
circadianGABAAhypothalamusmuscimolbicuculline
Abstract
Three independent electrophysiological approaches in hypothalamic slices were used to test the hypothesis that [.gamma]-amino butyric acid (GABA)Areceptor activation excites suprachiasmatic nucleus (SCN) neurons during the subjective day, consistent with a recent report. First, multiple-unit recordings during either the subjective day or night showed that GABA or muscimol inhibited firing activity of the SCN population in a dose-dependent manner. Second, cell-attached recordings during the subjective day demonstrated an inhibitory effect of bath-or microapplied GABA on action currents of single SCN neurons. Third, gramicidin perforated-patch recordings showed that bicuculline increased the spontaneous firing rate during the subjective day. Therefore, electrophysiological data obtained by three different experimental methods provide evidence that GABA is inhibitory rather than excitatory during the subjective day.
Department
Dept. of Medical Education (의학교육학)
Publisher
School of Medicine
Citation
Valentin K. Gribkoff et al. (1999). A Reexamination of the Role of GABA in the Mammalian Suprachiasmatic Nucleus. Journal of Biological Rhythms, 14(2), 126–130. doi: 10.1177/074873099129000515
Type
Article
ISSN
0748-7304
DOI
10.1177/074873099129000515
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33953
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
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