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Retargeting T Cell-Mediated Inflammation: A New Perspective on Autoantibody Action

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Affiliated Author(s)
박관규
Alternative Author(s)
Park, Kwan Kyu
Journal Title
Journal of Immunology
ISSN
0022-1767
Issued Date
2000
Abstract
To understand the pathogenesis of organ-specific autoimmune disease requires an appreciation of how the T cell-mediated inflammation is targeted, and how the organ function is compromised. In this study, autoantibody was documented to influence both of these parameters by modulating the distribution of T cell-mediated inflammation. The murine autoimmune ovarian disease is induced by immunization with the ZP3330–342 peptide of the ovarian zona pellucida 3 glycoprotein, ZP3. Passively transferred or actively induced Ab to ZP3335–342 bound to the zona pellucida in the functional and degenerative ovarian follicles, and the ovaries remained histologically normal. Transfer of ZP3330–342 peptide-specific T cells targeted the degenerative follicles and spared the functional follicles, and the resultant interstitial oophoritis was associated with unimpaired ovarian function. Unexpectedly, the coexistence of ZP3330–342 peptide-specific T cells and zona-bound autoantibody led to a dramatic translocation of the ovarian inflammation to the growing and mature ovarian follicles, with destruction of the ovarian functional unit. Ab retargeted both Th1-induced mononuclear inflammation and Th2-induced eosinophilic inflammation, and retargeting was induced by murine and rat polyclonal Abs to multiple distinct native B cell determinants of the zona pellucida. Therefore, by reacting with the native determinants in tissue Ag, Ab alters the distribution of T cell-mediated inflammation, and results in destruction of the functional units of the target organ. We propose that this is a clinically important and previously unappreciated element of Ab action in autoimmune disease.
Department
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Ya-Huan Lou et al. (2000). Retargeting T Cell-Mediated Inflammation: A New Perspective on Autoantibody Action. Journal of Immunology, 164(10), 5251–5257. doi: 10.4049/jimmunol.164.10.5251
Type
Article
ISSN
0022-1767
DOI
10.4049/jimmunol.164.10.5251
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34053
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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