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Increased Expression of Connexin43 on the Aortic Valve in the Hypercholesterolemic Rabbit Model

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Affiliated Author(s)
최미선
Alternative Author(s)
Choe, Mi Sun
Journal Title
Journal of Investigative Surgery
ISSN
0894-1939
Issued Date
2009
Keyword
Aortic valveAtherosclerosisGap junctionConnexin43Osteopontin
Abstract
Background: Aortic valve sclerosis is associated with increased risk of cardiovascular death and myocardial infarction. However, the relevance of connexin43 in aortic valve sclerosis remains unclear. We hypothesized that the mechanism regulating aortic valve sclerosis is associated with the alteration of cell-to-cell communication. Methods: Twenty male New Zealand rabbits were divided into two groups. Group 1 (n = 10) were fed a normal chow diet, while those in group 2 (n = 10) received a diet containing 1% cholesterol for 12 weeks. After utanizing the animals, the aortic valves were excised for analysis. Results: Myofibroblasts and macrophages were more highly expressed in the cholesterol diet group. Osteopontin and connexin43 were found to concentrate within the endothelial layer on the aortic side of the valve leaflets in the cholesterol diet group. A real-time polymerase chain reaction revealed increased connexin43 and osteopontin mRNA levels in the hypercholesterolemic aortic valves. Conclusions: The present study demonstrates that hypercholesterolemia increases the expression of connexin43 in the rabbit aortic valve. The results suggest that alterations in gap junctional intercellular communication via connexin43 gap junctions may play a role in the development of aortic valve sclerosis.
Department
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Young Pil Wang et al. (2009). Increased Expression of Connexin43 on the Aortic Valve in the Hypercholesterolemic Rabbit Model. Journal of Investigative Surgery, 22(2), 98–104. doi: 10.1080/08941930802713035
Type
Article
ISSN
0894-1939
DOI
10.1080/08941930802713035
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34062
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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