Clinical Characteristics of Idiopathic Pulmonary Fibrosis Patients with Diabetes Mellitus: the National Survey in Korea from 2003 to 2007
- Affiliated Author(s)
- 전영준
- Alternative Author(s)
- Jeon, Young June
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Issued Date
- 2012
- Keyword
- Idiopathic Pulmonary Fibrosis; Diabetes Mellitus; High Resolution Computed Tomography
- Abstract
- Evidence suggests that diabetes mellitus (DM) is associated with idiopathic
pulmonary fibrosis (IPF). According to the new IPF guidelines, high-resolution
computed tomography (HRCT) is an essential means of diagnosing IPF. We
investigated the relationship between IPF and DM in patients treated between
2003 and 2007. Newly diagnosed IPF patients in large university teaching
hospitals in Korea were enrolled from January 2003 to December 2007. We
retrospectively analyzed 1,685 patients using the interstitial lung disease (ILD)
registry. In total, 299 IPF patients (17.8%) also had DM. The mean age of our
subjects was 68.0 ± 9.4 yr. HRCT showed significantly more reticular and
honeycomb patterns in IPF patients with DM than in IPF patients without DM
(P = 0.014, P = 0.028, respectively). Furthermore, significantly higher incidences
of hypertension, cardiovascular diseases, and other malignancies (except lung
cancer) were found in IPF patients with DM than in IPF patients without DM. In
conclusion, IPF patients with DM are more likely to have the usual interstitial
pneumonia (UIP) pattern, including reticular and honeycomb patterns, on HRCT
than are those without DM.
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