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Development of an Animal Experimental Model for a Bileaflet Mechanical Heart Valve Prosthesis

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Affiliated Author(s)
박남희
Alternative Author(s)
Park, Nam Hee
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934
Issued Date
2004
Keyword
Surgical instrumentsProsthetic ValveCardiopulmonary BypassHemodynamic AssessmentHemodynamic Processes
Abstract
The objective of this study was to develop a pre-clinical large animal model for the
in vivo hemodynamic testing of prosthetic valves in the aortic position without the
need for cardiopulmonary bypass. Ten male pigs were used. A composite valved
conduit was constructed in the operating room by implanting a prosthetic valve
between two separate pieces of vascular conduits, which bypassed the ascending
aorta to the descending aorta. Prior to applying a side-biting clamp to the ascending
aorta for proximal grafting to the aortic anastomosis, an aorta to femoral artery
shunt was placed just proximally to this clamp. The heart rate, cardiac output,
Vmax, transvalvular pressure gradient, effective orifice area and incremental dobutamine
stress response were assessed. A dose dependant increase with dobutamine
was seen in terms of cardiac output, Vmax, and the peak transvalvular pressure
gradient both in the native and in the prosthetic valve. However, the increment
was much steeper in the prosthetic valve. No significant differences in cardiac
output were noted between the native and the prosthetic valves. The described
pre-clinical porcine model was found suitable for site-specific in-vivo hemodynamic
assessment of aortic valvular prosthesis without cardiopulmonary bypass.
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Publisher
School of Medicine
Citation
Suk Jung Choo et al. (2004). Development of an Animal Experimental Model for a Bileaflet Mechanical Heart Valve Prosthesis. Journal of Korean Medical Science, 19(1), 37–41. doi: 10.3346/jkms.2004.19.1.37
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2004.19.1.37
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34103
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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