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Involvement of Matrix Metalloproteinase in Neuroblast Cell Migration from the Subventricular Zone after Stroke

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Affiliated Author(s)
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Alternative Author(s)
Lee, Seong Ryong
Journal Title
Journal of Neuroscience
ISSN
0270-6474
Issued Date
2006
Keyword
neurogenesiscerebral ischemiaextracellular matrixstroke recoveryneural precursorstroke
Abstract
After brain injury, neuroblast cells from the subventricular zone (SVZ) expand and migrate toward damaged tissue. The mechanisms that
mediate these neurogenic and migratory responses remain to be fully dissected. Here, we show that bromodeoxyuridine-labeled and
doublecortin-positive cells from the SVZ colocalize with the extracellular protease matrix metalloproteinase-9 (MMP-9) during the 2
week recovery period after transient focal cerebral ischemia in mice. Treatment with the broad spectrum MMP inhibitor GM6001
significantly decreases the migration of doublecortin-positive cells that extend from the SVZ into the striatum. These data suggest that
MMPs are involved in endogenous mechanisms of neurogenic migration as the brain seeks to heal itself after injury.
Department
Dept. of Pharmacology (약리학)
Publisher
School of Medicine
Citation
Seong-Ryong Lee et al. (2006). Involvement of Matrix Metalloproteinase in Neuroblast Cell Migration from the Subventricular Zone after Stroke. Journal of Neuroscience, 26(13), 3491–3495. doi: 10.1523/JNEUROSCI.4085-05.2006
Type
Article
ISSN
0270-6474
DOI
10.1523/JNEUROSCI.4085-05.2006
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34190
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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