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Augmented death in immunostimulated astrocytes deprived of glucose: inhibition by an iron porphyrin FeTMPyP

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Affiliated Author(s)
신동훈
Alternative Author(s)
Shin, Dong Hoon
Journal Title
Journal of Neuroimmunology
ISSN
0165-5728
Issued Date
2001
Keyword
FeTMPyPGlucose deprivationPeroxynitriteMitochondria transmembrane potentialAstrocyte
Abstract
The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4′-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H2TMPyP, prevented the death in glucose-deprived immunostimulated astrocytes. Consistently, FeTMPyP, not ZnTMPyP and H2TMPyP, completely blocked the elevation of nitrotyrosine immunoreactivity (a marker of peroxynitrite) and the depolarization of the mitochondrial transmembrane potential in glucose-deprived immunostimulated astrocytes. The present data suggest that peroxynitrite may be associated with glial cell death during metabolic deterioration in the cerebral ischemic penumbra.
Department
Dept. of Preventive Medicine (예방의학)
Brain Research Institute (뇌연구소)
Publisher
School of Medicine
Citation
In Young Choi et al. (2001). Augmented death in immunostimulated astrocytes deprived of glucose:
inhibition by an iron porphyrin FeTMPyP. Journal of Neuroimmunology, 112(1–2), 55–62. doi: 10.1016/S0165-5728(00)00382-9
Type
Article
ISSN
0165-5728
DOI
10.1016/S0165-5728(00)00382-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34196
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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