Augmented death in immunostimulated astrocytes deprived of glucose:
inhibition by an iron porphyrin FeTMPyP
- Affiliated Author(s)
- 신동훈
- Alternative Author(s)
- Shin, Dong Hoon
- Journal Title
- Journal of Neuroimmunology
- ISSN
- 0165-5728
- Issued Date
- 2001
- Keyword
- FeTMPyP; Glucose deprivation; Peroxynitrite; Mitochondria transmembrane potential; Astrocyte
- Abstract
- The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4′-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H2TMPyP, prevented the death in glucose-deprived immunostimulated astrocytes. Consistently, FeTMPyP, not ZnTMPyP and H2TMPyP, completely blocked the elevation of nitrotyrosine immunoreactivity (a marker of peroxynitrite) and the depolarization of the mitochondrial transmembrane potential in glucose-deprived immunostimulated astrocytes. The present data suggest that peroxynitrite may be associated with glial cell death during metabolic deterioration in the cerebral ischemic penumbra.
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.