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Symptomatic Steno-occlusion of Cerebral Arteries and Subsequent Ischemic Events in Patients with Acute Ischemic Stroke

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Affiliated Author(s)
홍정호
Alternative Author(s)
Hong, Jeong Ho
Journal Title
Journal of Stroke and Cerebrovascular Diseases
ISSN
1052-3057
Issued Date
2014
Keyword
Ischemiastrokestenosisocclusionprognosis
Abstract
Background:

We aimed to assess the impact of symptomatic steno-occlusion (SYSO) of cerebral arteries and its characteristics on subsequent ischemic event (SIE) in patients with acute ischemic stroke.


Methods:

Using a prospective stroke registry database, we identified consecutive patients with ischemic stroke who were hospitalized within 48 hours of symptom onset. SYSO denoted significant stenosis or occlusion of major cerebral arteries with ischemic lesions at the corresponding arterial territories and was characterized by its location and severity. Primary outcome was SIE that was defined as ischemic progression or recurrence within 1 year.


Results:

In total, 1546 patients (age, 67.4 ± 13.0 years; median National Institutes of Health Stroke Scale score, 4) were enrolled in this study. The cumulative risk of SIE was 14.5% at 7 days, 14.9% at 14 days, 15.5% at 90 days, and 16.9% at 1 year. Patients with SYSO had significantly higher SIE rates compared with those without SYSO (23.0% versus 11.6%). Of the characteristics of SYSO, the location, not the severity, was significantly associated with SIE (P < .001 and P = .186, respectively). Multiple (adjusted hazard ratio, 5.85; 95% confidence interval, 1.81-18.85), intracranial internal carotid artery (ICA) (3.54; 1.21-8.21), and extracranial ICA SYSO (2.88; 1.01-8.21) raised the risk of SIE.


Conclusions:

Subsequent cerebral ischemic events (progression or recurrence) after an acute ischemic stroke occur mostly within several days of stroke onset and is associated with the location, but not the severity, of symptomatic steno-occlusion of cerebral arteries.
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
Jihoon Kang et al. (2014). Symptomatic Steno-occlusion of Cerebral Arteries
and Subsequent Ischemic Events in Patients with Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases, 23(5), e347–e353. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.028
Type
Article
ISSN
1052-3057
DOI
10.1016/j.jstrokecerebrovasdis.2013.12.028
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34258
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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