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Metastatic melanomas of unknown primary show better prognosis than those of known primary: A systematic review and meta-analysis of observational studies

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Affiliated Author(s)
오병호
Alternative Author(s)
Oh, Byung Ho
Journal Title
Journal of the American Academy of Dermatology
ISSN
0190-9622
Issued Date
2015
Keyword
malignant melanomamelanomamelanoma, unknown primarymeta-analysisprognosissystematic review
Abstract
Background:

Melanoma of unknown primary (MUP) is a condition of metastatic melanoma without a primary lesion.


Objective:

We sought to identify the prognosis of MUP compared with melanoma of known primary (MKP).


Methods:

We searched for observational studies containing at least 10 patients with MUP from MEDLINE and EMBASE from inception to December 22, 2012. The outcomes of interest were overall and disease-free survival; meta-analyses of hazard ratio stratified by stage using a random effects model were performed. In addition, second systematic review identified risk factors influencing the survival of patients with MUP.


Results:

Eighteen studies including 2084 patients with MUP and 5894 with MKP were included. MUP had a better overall survival compared with MKP in stage III (15 studies; hazard ratio 0.83, 95% confidence interval 0.73-0.96, P = .010) and stage IV (6 studies; hazard ratio 0.85, 95% confidence interval 0.75-0.96, P = .008). Secondly, 22 studies including 3312 patients with MUP were reviewed, and increased stage and old age were the risk factors in patients with MUP.


Limitations:

Diverse observational studies were reviewed, and selection and reporting biases are possible.


Conclusions:

The current meta-analyses suggest better survival outcomes in patients with MUP than those in patients with MKP with the same corresponding tumor stage.
Department
Dept. of Dermatology (피부과학)
Publisher
School of Medicine
Citation
Mi Ryung Roh et al. (2015). Metastatic melanomas of unknown primary show
better prognosis than those of known primary:
A systematic review and meta-analysis of
observational studies. Journal of the American Academy of Dermatology, 72(1), 59–70. doi: 10.1016/j.jaad.2014.09.029
Type
Article
ISSN
0190-9622
DOI
10.1016/j.jaad.2014.09.029
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34263
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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