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Clinical findings and outcomes in patients with possible usual interstitial pneumonia

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Affiliated Author(s)
이미영최원일노병학
Alternative Author(s)
Lee, Mi YoungChoi, Won IlRho, Byung Hak
Journal Title
Respiratory Medicine
ISSN
0954-6111
Issued Date
2015
Keyword
Idiopathic pulmonaryfibrosisPrognosisHRCT
Abstract
Background: Patients with possible usual interstitial pneumonia (UIP) constitute a substantialn group, and their clinical characteristics and outcomes are not well defined. We compared the clinical characteristics and survival between patients with possible UIP and the UIP pattern.
Methods: We evaluated 62 patients with possible UIP and 544 patients with the UIP pattern. Both groups were diagnosed by clinical characteristics and high-resolution computed tomography (HRCT) findings. Two radiologists performed radiological evaluation based on the new idiopathic pulmonary fibrosis (IPF) guidelines. Two risk-stratification methods were used to compare UIP pattern and possible UIP patients.
Results: The groups had similar demographic and clinical characteristics. Pulmonary function tests revealed no significant differences in lung volumes between the 2 groups. However, DLCO was significantly lower with the UIP pattern than with possible UIP (p=0.004). Multivariate analysis showed age, sex, and carbon monoxide diffusing capacity (DLCO) as important independent variables for survival. The UIP HRCT pattern did not affect survival (hazard ratio, 0.83; 95% confidence interval, 0.51-1.24; p=0.32). Possible UIP was not associated with prognosis when independent predictors for survival rate and propensity score were considered. In the case-control study, the 3-year survival rate was 44.6% in the UIP pattern group and 56.8% in the possible UIP group (p=0.16).
Department
Dept. of Preventive Medicine (예방의학)
Dept. of Internal Medicine (내과학)
Dept. of Radiology (영상의학)
Publisher
School of Medicine
Citation
Jin Wook Lee et al. (2015). Clinical findings and outcomes in patients with possible usual interstitial pneumonia. Respiratory Medicine, 109(4), 510–516. doi: 10.1016/j.rmed.2015.02.008
Type
Article
ISSN
0954-6111
DOI
10.1016/j.rmed.2015.02.008
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34341
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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