Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis

Authors
KYUNG-WOOK JOKYEONGMAN JEONYOUNG AE KANGWON-JUNG KOHKYUNG CHAN KIMYEE HYUNG KIMKWANG HA YOOSEUNG HEON LEEJAE-JOON YIMSANG BONG CHOIWON-IL CHOIJAE CHOL CHOIYONG IL HWANGTAE SUN SHIM
Department
Dept. of Internal Medicine (내과학)
Issue Date
2012
Citation
Respirology, Vol.17(7) : 1125-1130, 2012
ISSN
1323-7799
Abstract
Background and Objective: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). Methods: Close contacts of patients with bacteriologically confirmed MDR-TB (n=101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. Results: Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ=0.29). Conclusion: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination.
Keywords
close contactinterferon-γ assay,multidrug-resistant tuberculosistuberculin skin test
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34347
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
최원일
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1843.2012.02218.x
File in this Item
 사서에게 요청하기
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE