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Aberrant neural responses to social rejection in patients with schizophrenia

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Affiliated Author(s)
구정훈
Alternative Author(s)
Ku, Jeong Hun
Journal Title
Social Neuroscience
ISSN
1747-0919
Issued Date
2014
Keyword
Social rejectionSocial interactionSchizophreniaSuperior temporal sulcusFrontopolar cortex.
Abstract
Patients with schizophrenia often show abnormal social interactions, which may explain their social exclusion behaviors. This study aimed to elucidate patients’ brain responses to social rejection in an interactive situation. Fifteen patients with schizophrenia and 16 healthy controls participated in the functional magnetic resonance imaging experiment with the virtual handshake task, in which socially interacting contents such as acceptance and refusal of handshaking were implemented. Responses to the refusal versus acceptance conditions were evaluated and compared between the two groups. Controls revealed higher activity in the refusal condition compared to the acceptance condition in the right superior temporal sulcus, whereas patients showed higher activity in the prefrontal regions, including the frontopolar cortex. In patients, contrast activities of the right superior temporal sulcus were inversely correlated with the severity of schizophrenic symptoms, whereas contrast activities of the left frontopolar cortex were positively correlated with the current anxiety scores. The superior temporal sulcus hypoactivity and frontopolar hyperactivity of patients with schizophrenia in social rejection situations may suggest the presence of mentalizing deficits in negative social situations and inefficient processes of socially aberrant stimuli, respectively. These abnormalities may be one of the neural bases of distorted or paranoid beliefs in schizophrenia.
Department
Dept. of Biomedical Engineering (의용공학과)
Publisher
School of Medicine
Citation
Hyeongrae Lee et al. (2014). Aberrant neural responses to social rejection in patients with schizophrenia. Social Neuroscience, 9(4), 412–423. doi: 10.1080/17470919.2014.907202
Type
Article
ISSN
1747-0919
DOI
10.1080/17470919.2014.907202
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34412
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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