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Effect of Modified Polyhemoglobin on the Oxidative Damage After Ischemia-Reperfusion in the Liver

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Affiliated Author(s)
배재훈문교철김여희서성일김상표권택규황재석
Alternative Author(s)
Bae, Jae HoonMun, Kyo CheolKim, You HeeSuh, Seong IlKim, Sang PyoKwon, Taeg KyuHwang, Jae Seok
Journal Title
Transplantation Proceedings
ISSN
0041-1345
Issued Date
2003
Abstract
LIVER SUFFERS ischemia-reperfusion injury during
transplantation.1–3 Reactive oxygen species generated
by xanthine oxidase during reperfusion of the ischemic liver
might be in part responsible for the hepatic injury.4–6
Antioxidant enzymes, such as superoxide dismutase (SOD),
catalase, and glutathione peroxidase, remove oxygen free
radicals.7 Using glutaraldehyde we made cross-linked hemoglobin,
containing SOD and catalase, to protect against
ischemia-reperfusion injury during transplantation.
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