Effect of Modified Polyhemoglobin on the Oxidative Damage After Ischemia-Reperfusion in the Liver
- Affiliated Author(s)
- 배재훈; 문교철; 김여희; 서성일; 김상표; 권택규; 황재석
- Alternative Author(s)
- Bae, Jae Hoon; Mun, Kyo Cheol; Kim, You Hee; Suh, Seong Il; Kim, Sang Pyo; Kwon, Taeg Kyu; Hwang, Jae Seok
- Journal Title
- Transplantation Proceedings
- ISSN
- 0041-1345
- Issued Date
- 2003
- Abstract
- LIVER SUFFERS ischemia-reperfusion injury during
transplantation.1–3 Reactive oxygen species generated
by xanthine oxidase during reperfusion of the ischemic liver
might be in part responsible for the hepatic injury.4–6
Antioxidant enzymes, such as superoxide dismutase (SOD),
catalase, and glutathione peroxidase, remove oxygen free
radicals.7 Using glutaraldehyde we made cross-linked hemoglobin,
containing SOD and catalase, to protect against
ischemia-reperfusion injury during transplantation.
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