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Salvia plebeia Suppresses Atopic Dermatitis-Like Skin Lesions

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Affiliated Author(s)
권택규
Alternative Author(s)
Kwon, Taeg Kyu
Journal Title
American Journal of Chinese Medicine
ISSN
0192-415x
Issued Date
2014
Keyword
Salvia plebeiaAtopic DermatitisKeratinocytes
Abstract
Salvia plebeia R. Br. (Lamiaceae) has been used for folk medicines in Asian countries, including Korea and China, to treat skin inflammatory diseases and asthma. In this study, we investigated the effects of S. plebeia extract (SPE) on atopic dermatitis (AD)-like skin lesions and defined underlying mechanisms of action. We established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) to the ears. Repeated alternative treatment of DFE/DNCB caused AD-like skin lesions. The oral administration of SPE decreased AD symptoms based on ear thickness and histopathological analysis, in addition to serum IgE and IgG2a levels. SPE suppressed mast cell infiltration into the ear and serum histamine level. SPE inhibited Thl/Th2/Thl7 phenotype CD4+ T lymphocytes expansion in the lymph node and the expression of Thl/Th2/Thl7 cytokines in the ear tissue. To define the underlying mechanisms of action, the tumor necrosis factor (TNF)-a and interferon (IFN)-7 activated human keratinocytes (HaCaT) model was used. SPE significantly suppressed the expression of cytokines and chemokines through the down-regulation of mitogen-activated protein kinases, nuclear factor-rc B, and STAT1 in HaCaT cells. Taken together, our results suggest that SPE might be a candidate for the treatment of AD.
Keywords: Salvia plebeia; Atopic Dermatitis; Keratinocytes.
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Jin Kyeong Choi et al. (2014). Salvia plebeia Suppresses Atopic Dermatitis-Like Skin Lesions. American Journal of Chinese Medicine, 42(4), 967–985. doi: 10.1142/S0192415X1450061X
Type
Article
ISSN
0192-415x
DOI
10.1142/S0192415X1450061X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34463
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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