Paradoxical response in HIV-negative patients with pleural tuberculosis: a retrospective multicentre study

K. JeonW-I. ChoiJ. S. AnS. Y. LimW. J. KimG. M. ParkS. S. ParkH. S. ChoiB. H. LeeJ. C. ChoiM. J. NaJ. ParkJ. Y. Kim
Dept. of Internal Medicine (내과학)
Issue Date
International Journal of Tuberculosis and Lung Disease, Vol.16(6) : 846-851, 2012
OBJECTIVE: To evaluate the incidence, clinical characteristics and predicting factors for the development of paradoxical response in human immunodeficiency virus negative patients with isolated pleural tuberculosis (TB). DESIGN: A multicentre, retrospective cohort study including 458 patients who were diagnosed and treated with isolated pleural TB between March 2005 and February 2010. RESULTS: Paradoxical response developed in 72 patients (16%) with isolated pleural TB. The mean time to development of paradoxical response was 8.8 ± 6.4 weeks after initiation of anti-tuberculosis treatment. The main presentation of paradoxical response was aggravation of pre-existing pleural effusion in 58 patients (81%). However, the majority of the patients who developed paradoxical response had no associated symptoms (n = 49, 68%). In multiple logistic regression analysis, development of paradoxical response was independently associated with the proportion of eosinophils (adjusted OR 1.293, 95%CI 1.077–1.553) and protein concentrations (adjusted OR 0.590, 95%CI 0.397–0.878) in the pleural fluid at the time of diagnosis. CONCLUSION: Paradoxical response developed in 16% of the patients approximately 2 months after initiation of anti-tuberculosis treatment, presenting with aggravation of pre-existing pleural effusion. Development of paradoxical response was associated with the proportion of eosinophils and protein concentrations in the pleural fluid at the time of diagnosis. KEY WORDS: Mycobacterium tuberculosis; pleural effusion; incidence; risk factors
Mycobacterium tuberculosispleural effusionincidencerisk factors
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
Full Text
File in this Item
 사서에게 요청하기
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.