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A comparative study of high-dose hepatic arterial infusion chemotherapy and transarterial chemoembolization using doxorubicin for intractable, advanced hepatocellular carcinoma

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Affiliated Author(s)
장병국황재석
Alternative Author(s)
Jang, Byoung KukHwang, Jae Seok
Journal Title
Korean Jourmal of Hepatology
ISSN
1738-222X
Issued Date
2010
Keyword
CarcinomaHepatocellularHepatic arterial infusion chemotherapyTransarterial chemoembolizationDoxorubicin
Abstract
Background/aims: Transarterial chemoembolization (TACE) has long been used as a palliative therapy for unresectable hepatocellular carcinoma (HCC). High-dose hepatic arterial infusion chemotherapy (HAIC) has showed favorable outcomes in patients with intractable, advanced HCC. The aim of this study was to compare the effectiveness and safety of high-dose HAIC and conventional TACE using doxorubicin for advanced HCC.
Methods: The high-dose HAIC group comprised 36 patients who were enrolled prospectively from six institutions. The enrollment criteria were good liver function, main portal vein invasion (including vascular shunt), infiltrative type, bilobar involvement, and/or refractory to prior conventional treatment (TACE, radiofrequency ablation, or percutaneous ethanol injection), and documented progressive disease. Patients received 5-fluorouracil (500 mg/m(2) on days 1~3) and cisplatin (60 mg/m(2) on day 2 every 4 weeks) via an implantable port system. In the TACE group, 31 patients with characteristics similar to those in the high-dose HAIC group were recruited retrospectively from a single center. Patients underwent a transarterial infusion of doxorubicin every 4~8 weeks.
Results: Overall, 6 patients (8.9%) achieved a partial response and 20 patients (29.8%) had stable disease. The objective response rate (complete response+partial response) was significantly better in the high-dose HAIC group than in the TACE group (16.7% vs. 0%, P=0.030). Overall survival was longer in the high-dose HAIC group than in the TACE group (median survival, 193 vs. 119 days; P=0.026). There were no serious adverse effects in the high-dose HAIC group, while hepatic complications occurred more often in the TACE group.
Conclusions: High-dose HAIC appears to improve the tumor response and survival outcome compared to conventional TACE using doxorubicin in patients with intractable, advanced HCC
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Hee Yeon Kim et al. (2010). A comparative study of high-dose hepatic arterial infusion chemotherapy and transarterial chemoembolization using doxorubicin for intractable, advanced hepatocellular carcinoma. Korean Jourmal of Hepatology, 16(4), 355–361. doi: 10.3350/kjhep.2010.16.4.355
Type
Article
ISSN
1738-222X
DOI
10.3350/kjhep.2010.16.4.355
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34525
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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