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Patient's Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study

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Affiliated Author(s)
정치영전영준
Alternative Author(s)
Jung, Chi YoungJeon, Young June
Journal Title
Korean Journal of Internal Medicine
ISSN
1226-3303
Issued Date
2012
Keyword
PerceptionMorningSymptomsActivitiesChronic obstructive pulmonary disease
Abstract
Background/Aims

Patients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to assess the perception of COPD symptoms related to morning activities in patients with severe airflow limitation.


Methods

Data of 133 patients with severe airflow limitation were analyzed in a prospective, non-interventional study. A clinical symptom questionnaire was completed by patients at baseline. In patients having morning symptoms, defined by at least one or more prominent or aggravating symptom during morning activities, a morning activity questionnaire was also completed at baseline and following 2 months of COPD treatment.


Results

The most frequently reported COPD symptom was breathlessness (90.8%). Morning symptoms were reported in 76 (57%) patients; these had more frequent and severe clinical COPD symptoms. The most frequently reported morning activity was getting out of bed (82.9%). The long acting muscarinic antagonist (odds ratio [OR], 6.971; 95% confidence interval [CI], 1.317 to 11.905) and chest tightness (OR, 0.075; 95% CI, 0.011 to 0.518) were identified as significantly related to absence of morning symptoms. There was no significant correlation between the degree of forced expiratory volume in 1 second improvement and severity score differences of all items of morning activity after 2-month treatment.


Conclusions

Fifty-seven percent of COPD patients with severe airflow limitation have morning symptoms that limit their morning activities. These patients also have more prevalent and severe COPD symptoms. The results of this study therefore provide valuable information for the development of patient-reported outcomes in COPD.

Keywords: Perception, Morning, Symptoms, Activities, Chronic obstructive pulmonary disease
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Yeon Jae Kim et al. (2012). Patient’s Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study. Korean Journal of Internal Medicine, 27(4), 426–435. doi: 10.3904/kjim.2012.27.4.426
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2012.27.4.426
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34575
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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