Primary Pulmonary Biphasic Synovial Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Gene: Report of 1 Case

Authors
Jae Seok ParkBo Ram MinSoon Hyo ParkKun Young KwonDong-Yoon KeumWon-Il Choi
Department
Dept. of Internal Medicine (내과학); Dept. of Pathology (병리학); Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Issue Date
2010
Citation
Korean Journal of Internal Medicine, Vol.25(3) : 331-336, 2010
ISSN
1226-3303
Abstract
We experienced a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by immunohistochemistry and molecular testing of SYT-SSX2 fusion transcripts. The patient was a 61-year-old man who presented with a well-defined mass in the left upper lung field on chest radiography. Left upper lobectomy with lymph node dissection was performed. Histological and immunophenotypic features were consistent with biphasic synovial sarcoma. Reverse transcriptase polymerase chain reaction, performed using RNA extracted from frozen tumor samples for the detection of SYT-SSX fusion gene, amplified a single 331-bp fragment that was characteristic of the SYT-SSX2 fusion transcripts. We report a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by SYT-SSX2 fusion transcripts, and present a brief review of the literature on Korean cases. Keywords: Sarcoma, synovial; Lung neoplasms; Gene fusion
Keywords
SarcomasynovialLung neoplasmsGene fusion
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34576
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Keimyung Author(s)
박재석; 최원일; 권건영; 금동윤
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