한국 소아 청소년기 림프종의 아형별 분포 및 특성

Abstract

Background: The Hematopathology Study Group of the Korean Society of Pathologists con-ducted a nation-wide retrospective analysis of Korean pediatric lymphoma, to provide patho-logic data on pediatric/adolescent lymphoma subtypes and features. Methods: All lymphoma cases of all age groups were collected during a recent 2 year-period (2005-2006) from 32 insti-tutes in Korea. Among 3,686 lymphoma patients, 142 who were age 18 or less were classi-fied according to the World Health Organization (WHO) classification. Results: Among 142 pediatric/adolescent lymphoma patients, Hodgkin lymphoma accounted for 21 (14.8%) and non-Hodgkin lymphoma (NHL) for 121 (85.2%). Hodgkin lymphoma appears to be more com-mon in the pediatric/adolescent age group than in the all-ages group (14.8% vs 4.4%). T- and natural killer cell-NHL was more common in the pediatric/adolescent age group than in the all ages group (46.3% vs 22%). The majority of Korean pediatric/adolescent NHL cases was composed of Burkitt lymphoma, T- or B-lymphoblastic lymphoma, anaplastic large-cell lymphom-a, and diffuse large B-cell lymphoma. For lymphoma patients under the age of 6 years, most had B-lymphoblastic or Burkitt lymphoma, which commonly presented at extranodal sites. Conclusions: The distribution of lymphoma subtypes in the pediatric/adolescent age group is quite different from the distribution of adults, but it was quite similar to distribution in West-ern countries.

Key Words: Pediatric lymphoma; Incidence; Korea; Lymphoma