Background: The aim of this study was to evaluate the prevalence, risk factors, and
survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF).
Methods: IPF with lung cancer from tertiary hospitals consisted of 1685 patients
who had been diagnosed between 2003 and 2007. We reviewed their medical records
retrospectively to evaluate the prevalence, risk factors and prognosis of lung cancer
in IPF patients.
Results: Among all patients with IPF, 114 cases (6.8%) had lung cancer with
IPF. The incidence of lung cancer in patients with IPF was 1.03 persons per 100
person-year (25 patients/2408 years). Most cases of lung cancer (73/114, 68.9%)
were located in IPF-associated areas; the lung cancer typically developed in periph-
eral and lower lobe areas. The study revealed that forced vital capacity (% predicted)
at the initial diagnosis and development of lung cancer were independent prognostic
factors in patients with IPF.
Conclusions: Lung cancer in patients with IPF was significantly related with the IPF
prognosis. An active evaluation should be performed in patients with IPF to detect
lung cancer early.
idiopathic pulmonary fibrosis; lung cancer;