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Allograft Mucormycosis Due to Rhizopus microsporus in a Kidney Transplant Recipient

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Affiliated Author(s)
박우영황은아한승엽박성배최미선김형태
Alternative Author(s)
Park, Woo YoungHwang, Eun AhHan, Seung YeupPark, Sung BaeChoe, Mi SunKim, Hyoung Tae
Journal Title
Transplantation Proceedings
ISSN
0041-1345
Issued Date
2014
Abstract
Mucormycosis is an uncommon infectious complication with fatal outcome after kidney
transplantation. We describe a rare form of mucormycosis in allograft kidney. The patient
was a 54-year-old man who underwent deceased-donor transplantation. The patient
experienced delayed graft function and new-onset diabetes within 1 week after trans-
plantation. Four weeks after transplantation, he was readmitted because of allograft
dysfunction without fever or pain. Ultrasonography showed enlarged allograft with normal
blood flow. He was received broad antibiotics for 6 days, but allograft function was not
recovered. Seven days after admission, allograft biopsy was performed, and in microscopic
examination, extensive necrotic areas with disseminated fungal invasion were seen, and it
was identified as Rhizopus microsporus by culture and DNA analysis. With allograft ne-
phrectomy, he was treated with amphotericin B. Despite intensive antifungal drugs after
graft nephrectomy, the patient died of disseminated fungal infection.
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