Significance of IL-2, IL-2R, IL-6, and TNF-Alpha as a Diagnostic Test of Acute Rejection After Renal Transplantation

Authors
W.H. ChoH.T. KimC.Y. SohnC.H. ParkS.B. ParkH.C. Kim
Department
Dept. of Internal Medicine (내과학); Dept. of Urology (비뇨의학); Dept. of Surgery (외과학); Institute for Medical Science (의과학연구소)
Issue Date
1998
Citation
Transplantation Proceedings, Vol.30(7) : 2967-2969, 1998
ISSN
0041-1345
Abstract
ACUTE REJECTION of the graft is a complex process which results in tissue edema, infiltration of inflam- matory cells, thrombosis in the microcirculation due to reaction of immune cells, and, finally, tissue necrosis. After introduction of advanced immunosuppressant including cyclosporin, classic clinical findings are missed frequently, so that the diagnosis of rejection becomes difficult. Graft biopsy makes most definitive diagnosis of rejection, but it is invasive and may cause serious complications. Various efforts have been made for early diagnosis by checking immune cells and its products using molecular techniques. Among them, measurement of cytokines in the blood and graft excretion1–4 is under investigation. In the present report, serum interleukin–2 (IL–2), inter- leukin–2 receptor (IL–2R), interleukin–6 (IL–6), and tu- mor necrosis factor (TNF)–a of renal transplant recipients were serially measured for 1 month after transplantation; the changes in rejection group compared with the non– rejection group, and the differences checked according to the response of the steroid pulse therapy in case of acute rejection.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34694
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
Keimyung Author(s)
박성배; 김현철; 박철희; 조원현; 김형태
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134598008926?via%3Dihub
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