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Significance of IL-2, IL-2R, IL-6, and TNF-Alpha as a Diagnostic Test of Acute Rejection After Renal Transplantation

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Author(s)
박성배김현철박철희조원현김형태
Alternative Author(s)
Park, Sung BaeKim, Hyun ChulPark, Choal HeeCho, Won HyunKim, Hyoung Tae
Publication Year
1998
Abstract
ACUTE REJECTION of the graft is a complex process
which results in tissue edema, infiltration of inflam-
matory cells, thrombosis in the microcirculation due to
reaction of immune cells, and, finally, tissue necrosis. After
introduction of advanced immunosuppressant including
cyclosporin, classic clinical findings are missed frequently,
so that the diagnosis of rejection becomes difficult. Graft
biopsy makes most definitive diagnosis of rejection, but it is
invasive and may cause serious complications. Various
efforts have been made for early diagnosis by checking
immune cells and its products using molecular techniques.
Among them, measurement of cytokines in the blood and
graft excretion1–4
is under investigation.
In the present report, serum interleukin–2 (IL–2), inter-
leukin–2 receptor (IL–2R), interleukin–6 (IL–6), and tu-
mor necrosis factor (TNF)–a of renal transplant recipients
were serially measured for 1 month after transplantation;
the changes in rejection group compared with the non–
rejection group, and the differences checked according to
the response of the steroid pulse therapy in case of acute
rejection.
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