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Significance of IL-2, IL-2R, IL-6, and TNF-Alpha as a Diagnostic Test of Acute Rejection After Renal Transplantation

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Author(s)
W.H. ChoH.T. KimC.Y. SohnC.H. ParkS.B. ParkH.C. Kim
Publication Year
1998
Abstract
ACUTE REJECTION of the graft is a complex process
which results in tissue edema, infiltration of inflam-
matory cells, thrombosis in the microcirculation due to
reaction of immune cells, and, finally, tissue necrosis. After
introduction of advanced immunosuppressant including
cyclosporin, classic clinical findings are missed frequently,
so that the diagnosis of rejection becomes difficult. Graft
biopsy makes most definitive diagnosis of rejection, but it is
invasive and may cause serious complications. Various
efforts have been made for early diagnosis by checking
immune cells and its products using molecular techniques.
Among them, measurement of cytokines in the blood and
graft excretion1–4
is under investigation.
In the present report, serum interleukin–2 (IL–2), inter-
leukin–2 receptor (IL–2R), interleukin–6 (IL–6), and tu-
mor necrosis factor (TNF)–a of renal transplant recipients
were serially measured for 1 month after transplantation;
the changes in rejection group compared with the non–
rejection group, and the differences checked according to
the response of the steroid pulse therapy in case of acute
rejection.
Department
Dept. of Internal Medicine (내과학)
Dept. of Urology (비뇨의학)
Dept. of Surgery (외과학)
Institute for Medical Science (의과학연구소)
Publisher
School of Medicine
Citation
Transplantation Proceedings, Vol.30(7) : 2967-2969, 1998
Type
Article
ISSN
0041-1345
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34694
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