Total Antioxidant Status and Oxygen Free Radicals During Hepatic Regeneration
- 곽춘식; 문교철; 한승엽; 박성배; 김현철; 남성일
- Alternative Author(s)
- Kwak, Chun Sik; Mun, Kyo Cheol; Han, Seung Yeup; Park, Sung Bae; Kim, Hyun Chul; Nam, Sung Il
- Publication Year
- Objectives. The damage induced by oxygen free radicals (OFRs) is caused by an
imbalance of the production of versus the antioxidant defenses against OFRs.
Methods. To understand hepatic damage induced by oxygen free radicals after hepa-
tectomy in rats, total antioxidant status and total production of oxygen free radicals were
serially measured in regeneration liver. At 1, 2, 3, 7, and 10 days after hepatectomy of
Sprague-Dawley rats, blood was obtained into a capillary tube from a tail vein. Total
antioxidant status and total production of oxygen free radicals were measured using the
Randox kit, a colorimetric method, and the Free Radical Analytical System.We also measured
the amount of malonyldialdehyde, which provides an indirect index of oxidative injury.
Results. The level of malonyldialdehyde after hepatectomy was higher compared with
that before hepatectomy. The level of total oxygen free radicals after hepatectomy was
higher compared with that before hepatectomy. Total antioxidant status after hepatectomy
was lower compared with that before hepatectomy.
Conclusions. The results suggested that the damage by OFRs to the regenerating liver was
caused by increased production of OFRs and decreased antioxidant defense against OFRs
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