Total Antioxidant Status and Oxygen Free Radicals During Hepatic Regeneration

Authors
S.Y. HanE.J. ChangH.J. ChoiS.I. NamN.H. LeeC.S. KwakS.B. ParkH.C. KimK.C. Mun
Department
Dept. of Biochemistry (생화학); Dept. of Internal Medicine (내과학); Dept. of Otorhinolaryngology (이비인후과학); Kidney Institute (신장연구소)
Issue Date
2006
Citation
Transplantation Proceedings, Vol.38(7) : 2214-2215, 2006
ISSN
0041-1345
Abstract
Objectives. The damage induced by oxygen free radicals (OFRs) is caused by an imbalance of the production of versus the antioxidant defenses against OFRs. Methods. To understand hepatic damage induced by oxygen free radicals after hepa- tectomy in rats, total antioxidant status and total production of oxygen free radicals were serially measured in regeneration liver. At 1, 2, 3, 7, and 10 days after hepatectomy of Sprague-Dawley rats, blood was obtained into a capillary tube from a tail vein. Total antioxidant status and total production of oxygen free radicals were measured using the Randox kit, a colorimetric method, and the Free Radical Analytical System.We also measured the amount of malonyldialdehyde, which provides an indirect index of oxidative injury. Results. The level of malonyldialdehyde after hepatectomy was higher compared with that before hepatectomy. The level of total oxygen free radicals after hepatectomy was higher compared with that before hepatectomy. Total antioxidant status after hepatectomy was lower compared with that before hepatectomy. Conclusions. The results suggested that the damage by OFRs to the regenerating liver was caused by increased production of OFRs and decreased antioxidant defense against OFRs
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34702
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Kidney Institute (신장연구소)
Keimyung Author(s)
곽춘식; 문교철; 한승엽; 박성배; 김현철; 남성일
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134506008529?via%3Dihub
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