Effect of AP-1 Decoy Using Hemagglutinating Virus of Japan-Liposome on the Intimal Hyperplasia of the Autogenous Vein Graft in Mongrel Dogs

Authors
W.H. ChoH.T. KimJ.H. KooI.K. Lee
Department
Dept. of Surgery (외과학)
Issue Date
2006
Citation
Transplantation Proceedings, Vol.38(7) : 2161-2163, 2006
ISSN
0041-1345
Abstract
Intimal hyperplasia is the leading cause of late vein graft failure. Smooth muscle cell proliferation and migration is the underlying mechanism. Pharmacological approaches to prolong vein graft patency have produced limited results. AP-1 proteins play a role in the expression of many genes involved in cellular proliferation and cell cycle progression. Previously we reported inhibition of vascular smooth muscle cell migration, proliferation, and intimal hyperplasia in the balloon-injured rat carotid artery using an AP-1 decoy with HVJ-liposomes. In this report, we evaluated the effect of the AP-1 decoy on intimal hyperplasia in a large animal model. The jugular vein was transfected with hemaggluti- nating virus of Japan-liposomes containing the AP-1 decoy or scrambled oligonucleotides. An interposition graft was performed with the pretreated jugular vein between the transected femoral arteries. The graft was harvested at 16 weeks after the procedure. The intimal area was compared: the intimal area of the AP-1 decoy-treated versus control group was 47.3±15.2 versus 102.3± 15.9 (P < .05), respectively. In conclusion, AP-1 decoy using HVJ-liposomes effectively prevented intimal hyperplasia of an autogenous vein graft in mongrel dogs.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34705
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
Keimyung Author(s)
조원현; 김형태
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134506007494?via%3Dihub
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