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Effect of Modified Polyhemoglobin on the Ischemia/Reperfusion Injury in Kidney

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Affiliated Author(s)
문교철곽춘식김상표박성배김현철김여희
Alternative Author(s)
Park, Sung BaeKim, Hyun ChulKim, You HeeMun, Kyo CheolKwak, Chun SikKim, Sang Pyo
Journal Title
Transplantation Proceedings
ISSN
0041-1345
Issued Date
2003
Abstract
DURING TRANSPLANTATION the kidney suffers an
ischemia/reperfusion injury.¹,²
Reactive oxygen spe-
cies generated by xanthine oxidase during reperfusion of
the ischemic kidney may be in par responsible for the renal
injury.¹,²
Oxygen free radicals are removed by antioxidant
enzymes such as superoxide dismutase (SOD), catalase, and
glutathione peroxidase.³
Using glutaraldehyde we sought to
cross-link hemoglobin containing SOD and catalase to
protect the kidney from an ischemia/reperfusion injury
during transplantation.
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