Comparison of the Safety and Efficacy of Mycophenolate Mofetil, Prednisolone and Cyclosporine and Conventional Cyclosporine and Prednisolone in Kidney Transplantation

Abstract

MYCOPHENOLATE mofetil (MMF) is a potent and selective inhibitor of B- and T-lymphocyte prolifer- ation that has proven effective in reducing the incidence of acute rejection in cadaveric kidney transplant recipients in several randomized clinical studies.¹-³ We conducted a nonrandomized prospective study to compare the efficacy and safety of triple-drug therapy with MMF (1 g b.i.d) and conventional double drug regimen (cyclosporine and pred- nisolone).