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Effect of Melatonin on the Antioxidant Enzymes in the Kidneys of Cyclosporine-Treated Rats

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Affiliated Author(s)
문교철
Alternative Author(s)
Mun, Kyo Cheol
Journal Title
Transplantation Proceedings
ISSN
0041-1345
Issued Date
2002
Abstract
The pathophysiology of cyclosporine (CsA)-induced nephrotoxicity remains unclear, however, experimental and clinical data strongly suggest that CsA-induced nephrotoxicity results from increased production of free radicals exclusive for the kidney.¹ Melatonin has been reported to have antioxidant properties in addition to its known hormonal activities.²,³ It is an effective scavenger of both the highly toxic hydroxyl and peroxyl radicals.³ Additionally, melatonin may stimulate antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase.³ Thus, melatonin exerts a protective effect on CsA-induced nephrotoxicity.⁴ To study the mechanisms of the protective effect of melatonin on CsA-induced nephrotoxicity, we measured malondialdehyde content, antioxidant enzyme activities, and reverse transcription–polymerase chain reaction (RT-PCR) for SOD.
Department
Dept. of Biochemistry (생화학)
Kidney Institute (신장연구소)
Publisher
School of Medicine
Citation
Y.H. Kim et al. (2002). Effect of Melatonin on the Antioxidant Enzymes in the Kidneys of Cyclosporine-Treated Rats. Transplantation Proceedings, 34(7), 2650–2651. doi: 10.1016/S0041-1345(02)03461-9
Type
Article
ISSN
0041-1345
DOI
10.1016/S0041-1345(02)03461-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34740
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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