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Effect of Melatonin on the Antioxidant Enzymes in the Kidneys of Cyclosporine-Treated Rats

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Author(s)
문교철
Alternative Author(s)
Mun, Kyo Cheol
Publication Year
2002
Abstract
The pathophysiology of cyclosporine (CsA)-induced nephrotoxicity remains unclear, however, experimental and clinical data strongly suggest that CsA-induced nephrotoxicity results from increased production of free radicals exclusive for the kidney.¹ Melatonin has been reported to have antioxidant properties in addition to its known hormonal activities.²,³ It is an effective scavenger of both the highly toxic hydroxyl and peroxyl radicals.³ Additionally, melatonin may stimulate antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase.³ Thus, melatonin exerts a protective effect on CsA-induced nephrotoxicity.⁴ To study the mechanisms of the protective effect of melatonin on CsA-induced nephrotoxicity, we measured malondialdehyde content, antioxidant enzyme activities, and reverse transcription–polymerase chain reaction (RT-PCR) for SOD.
Department
Dept. of Biochemistry (생화학)
Kidney Institute (신장연구소)
Publisher
School of Medicine
Citation
Transplantation Proceedings, Vol.34(7) : 2650-2651, 2002
Type
Article
ISSN
0041-1345
DOI
10.1016/S0041-1345(02)03461-9
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34740
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