Effect of Melatonin on the Antioxidant Enzymes in the Kidneys of Cyclosporine-Treated Rats
- Affiliated Author(s)
- 문교철
- Alternative Author(s)
- Mun, Kyo Cheol
- Journal Title
- Transplantation Proceedings
- ISSN
- 0041-1345
- Issued Date
- 2002
- Abstract
- The pathophysiology of cyclosporine (CsA)-induced nephrotoxicity remains unclear, however, experimental and clinical data strongly suggest that CsA-induced nephrotoxicity results from increased production of free radicals exclusive for the kidney.¹ Melatonin has been reported to have antioxidant properties in addition to its known hormonal activities.²,³ It is an effective scavenger of both the highly toxic hydroxyl and peroxyl radicals.³ Additionally, melatonin may stimulate antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase.³ Thus, melatonin exerts a protective effect on CsA-induced nephrotoxicity.⁴ To study the mechanisms of the protective effect of melatonin on CsA-induced nephrotoxicity, we measured malondialdehyde content, antioxidant enzyme activities, and reverse transcription–polymerase chain reaction (RT-PCR) for SOD.
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.