Historical Comparison of Prophylactic Ganciclovir for Gastrointestinal Cytomegalovirus Infection in Kidney Transplant Recipients

Authors
H.C. KimE.A. HwangS.B. ParkH.T. KimW.H. Cho
Department
Dept. of Internal Medicine (내과학); Dept. of Surgery (외과학); Kidney Institute (신장연구소)
Issue Date
2012
Citation
Transplantation Proceedings, Vol.44(3) : 710-712, 2012
ISSN
0041-1345
Abstract
Background Cytomegalovirus (CMV) can cause morbidity in kidney transplant recipients. The gastrointestinal (GI) tract is a major target for CMV disease. The aim of this study was to evaluate the benefit of ganciclovir prophylaxis on GI CMV infection in intermediate-risk CMV seropositive transplant recipients. Methods Since January 2009, intravenous ganciclovir (5 mg/kg, twice daily) was administered for 14 days after kidney transplantation in 41 patients. The historical control group consisted of 45 patients who received kidney transplantations between January 2007 and December 2008. To evaluate the effects of prophylaxis on GI CMV infection, we performed routine endoscopic examinations with mucosal biopsies at the time of transplantation as well as 1, 3, and 6 months thereafter. Results The average age of the 86 studied patients was 43.7 ± 10.6 years (range = 14–63) and the male-to-female ratio 1:1.3. Forty-three (50%) patients underwent deceased donor transplantations and 84 (97.7%) patients were CMV seropositive at that time. The incidence of GI CMV infection was significantly lower among the prophylaxis than the historical control group (24.4% vs 48.9%, P = .026). Patient age, numbers of deceased donors, and tacrolimus trough levels at 1 and 3 months posttransplant were significantly lower in the prophylaxis than the historical control group. Logistic regression analysis revealed ganciclovir prophylaxis to be the only significant risk factor for GI CMV infection. Conclusion Prophylactic treatment with ganciclovir decreased the incidence GI CMV infection among seropositive kidney transplant recipients.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34747
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Kidney Institute (신장연구소)
Keimyung Author(s)
김현철; 황은아; 박성배; 김형태; 조원현
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134511016381?via%3Dihub
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