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Reevaluation of Experimental Model of Hepatic Fibrosis Induced by Hepatotoxic Drugs: An Easy, Applicable, and Reproducible Model

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Author(s)
J.H. JangK.J. KangY.H. KimY.N. KangI.S. Lee
Publication Year
2008
Abstract
Establishing an easy and reproducible model for hepatic fibrosis is absolutely necessary for research on liver reperfusion injury. We compared the characteristics of several hepatic cirrhosis models in terms of the degree of fibrosis, reproducibility, histologic characteristics, and success rate to achieve sufficient fibrosis. In mice & rats, we administered three different hepatotoxic drugs (thioacetamide, dimethylnitrosamine, and carbon tetrachloride [CCl4]) through two different routes (oral feeding and intraperitoneal injection). The animals fed thioacetamide exhibited little fibrosis; rather, more inflammatory cells infiltrated into periportal areas with bile duct proliferation. The livers from hosts administered dimethylnitrosamine showed greater early injury and severe inflammatory reactions in the peritoneal cavity. The liver showed a marked degree of piecemeal necrosis with limited fibrosis. The mice administered a 50% solution of CCl4 (2 mL/kg orally) tolerated the entire induction period of 12 weeks. The degree of fibrosis correlated well with the duration of induction. Livers from hosts administered CCl4 orally twice a week for 10 weeks was the most effective to achieve sufficient fibrosis and greatest reproducibility with acceptable animal survival.
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Institute for Medical Science (의과학연구소)
Publisher
School of Medicine
Citation
Transplantation Proceedings, Vol.40(8) : 2700-2703, 2008
Type
Article
ISSN
0041-1345
DOI
10.1016/j.transproceed.2008.07.040
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34763
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