Dept. of Internal Medicine (내과학); Dept. of Pathology (병리학); Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Tuberculosis and Respiratory Diseases, Vol.71(5) : 363-367, 2011
Lymphoepithelioma-like carcinoma (LELC) of the lung is a very rare tumor. Originally described in the nasopharynx
as lymphoepithelioma, this carcinoma has also been found in the stomach, esophagus, thymus, cervix, urinary
bladder, skin, and salivary glands. Histologically, it is an undifferentiated carcinoma that has a syncytial appearance
with tumor cells and is infiltrated by numerous lymphocytes, macrophages, and plasma cells. LELC of the lung
occurs more commonly in Asians, particularly Chinese. Many studies have reported the association between
Epstein-Barr virus (EBV) and LELC of the lung in Asian patients. A 45-year-old man had a solitary pulmonary
nodule on a routine chest X-ray examination. As a malignant tumor was suspected, surgical resection was
performed to establish the correct diagnosis. The pathology of the excised tumor demonstrated LELC of the lung.
This is the first report of LELC of the lung in Korea.
Key Words: Carcinoma, Non-Small-Cell Lung; Solitary Pulmonary Nodule; Lung Neoplasms; Herpesvirus 4, Human