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Relationships between the Effect of Sunitinib and Immature Blood Vessels in Metastatic Renal Cell Cancer

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Author(s)
김병훈박철희김천일최미선정혜라
Alternative Author(s)
Kim, Byung HoonPark, Choal HeeKim, Chun IlChoe, Mi SunJung, Hye Ra
Publication Year
2015
Keyword
Renal cellAngiogenesisMetastasisDisease progression
Abstract
Introduction: This study was conducted to investigate the relationships between the effect of sunitinib and immature microvessels which are not covered by pericytes. Materials and Methods: This study involved 29 patients with clear-cell renal cell carcinoma (RCC) who took sunitinib after radical nephrectomy or biopsy due to metastatic RCC. Associations among clinicopathological factors, responses to sunitinib, and patient survival were reviewed. CD31 was used to stain endothelial cells, and anti-α-smooth muscle actin was used to stain pericytes. Immature vessels were defined as vessels that were positive only for CD31 staining. A high pericyte coverage was defined as a rate of pericyte coverage above 40%. Results: Partial responses, disease stabilization, and disease progression constituted 51.7, 10.4, and 37.9% of cases, respectively. Nine cases had a low pericyte coverage (31.0%). In the high-pericyte-coverage group, the number of metastatic sites was smaller (p = 0.003). The overall response rate to sunitinib was greater in the high-pericyte-coverage group than in the low-pericyte-coverage group (p = 0.027). The median overall survival and the median progression-free survival were not significantly different between the high- and low-pericyte-coverage groups. Conclusion: In the high-pericyte-coverage group, the overall response rates to sunitinib were higher, and the numbers of metastatic sites were smaller.
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Urologia Internationalis, Vol.94(2) : 137-143, 2015
Type
Article
ISSN
0042-1138
DOI
10.1159/000363773
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34803
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