Gynecologic Cancer InterGroup (GCIG) Consensus Review for Mullerian Adenosarcoma of the Female Genital Tract
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- Kwon, Sang Hoon
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- Mullerian adenosarcomas of the female genital tract are rare malignancies, originally described
in the uterus, the most common site of origin, but they may also arise in extrauterine
locations. Uterine adenosarcomas make up 5% of uterine sarcomas and tend to occur in
postmenopausal women. They are usually low-grade tumors and are characterized by a
benign epithelial component with a malignant mesenchymal component, which is typically
a low-grade endometrial stromal sarcoma but can also be a high-grade sarcoma. Tumors
that exhibit a high-grade sarcomatous overgrowth have a worse outcome. Adenosarcomas
have been described as being midway along the spectrum between benign adenofibromas
and carcinosarcomas. They generally have a good prognosis with the exception
of deeply invasive tumors or those with high-grade sarcomatous overgrowth. Extrauterine
adenosarcomas also have a higher risk for recurrence. In view of their rarity, there
have not been any clinical trials in mullerian adenosarcomas and relatively little research.
This article reviews the current knowledge and provides recommendation for the management
of mullerian adenosarcomas.
Key Words: Mullerian adenosarcoma review
Received April 18, 2014, and in revised form July 13, 2014.
Accepted for publication July 13, 2014.
(Int J Gynecol Cancer 2014;24: S78YS82)
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