Complexity in Regulation of microRNA Machinery Components in Invasive Breast Carcinoma

Authors
Sun Young KwonJae-ho LeeBora KimJong-Wook ParkTaeg Kyu KwonSun Hee KangShin Kim
Department
Dept. of Surgery (외과학); Dept. of Immunology (면역학); Dept. of Anatomy (해부학); Dept. of Pathology (병리학)
Issue Date
2014
Citation
Pathology & Oncology Research, Vol.20(3) : 697-705, 2014
ISSN
1219-4956
Abstract
Altered expression of microRNA (miRNA) machinery components may play an important role in breast cancer progression. The objective of the current study was to evaluate Drosha, the DiGeorge syndrome critical region gene 8 (DGCR8), Dicer, and Argonaute 2 (AGO2) mRNA expression in invasive breast carcinoma (IBC) and to assess the value of clinical parameters on their expression. By using quantitative real-time PCR, we examined the expression of the four miRNA machinery components in 52 breast tumor tissues which are diagnosed as invasive ductal carcinoma and adjacent non-neoplastic tissues. In the present study, decreased mRNA expression levels of major miRNA machinery components were observed in IBC. The altered mRNA expression levels ofDGCR8 and AGO2 are positively correlated with to each other. This study revealed for the first time that expression alterations of DGCR8 are significantly associated with estrogen receptor and Ki-67 status in IBC. Moreover, AGO2 mRNA expression level was significantly correlated with N stage. These results provided evidences that downregulated the four miRNA machinery components may play an important role in breast pathobiology and that DGCR8 and AGO2 might be associated with important clinical factors. Keywords microRNAbiogenesis .DGCR8 . AGO2 . Ki-67 . Invasive breast carcinoma
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34832
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
강선희; 박종욱; 권택규; 김신; 이재호; 권선영
Full Text
https://link.springer.com/article/10.1007%2Fs12253-014-9750-5
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