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Complexity in Regulation of microRNA Machinery Components in Invasive Breast Carcinoma

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Affiliated Author(s)
강선희박종욱권택규김신이재호권선영
Alternative Author(s)
Kang, Sun HeePark, Jong WookKwon, Taeg KyuKim, ShinLee, Jae HoKwon, Sun Young
Journal Title
Pathology & Oncology Research
ISSN
1219-4956
Issued Date
2014
Abstract
Altered expression of microRNA (miRNA) machinery
components may play an important role in breast
cancer progression. The objective of the current study was to
evaluate Drosha, the DiGeorge syndrome critical region gene
8 (DGCR8), Dicer, and Argonaute 2 (AGO2) mRNA expression
in invasive breast carcinoma (IBC) and to assess the
value of clinical parameters on their expression. By using
quantitative real-time PCR, we examined the expression of
the four miRNA machinery components in 52 breast tumor
tissues which are diagnosed as invasive ductal carcinoma and
adjacent non-neoplastic tissues. In the present study, decreased
mRNA expression levels of major miRNA machinery
components were observed in IBC. The altered mRNA expression
levels ofDGCR8 and AGO2 are positively correlated
with to each other. This study revealed for the first time that
expression alterations of DGCR8 are significantly associated
with estrogen receptor and Ki-67 status in IBC. Moreover,
AGO2 mRNA expression level was significantly correlated
with N stage. These results provided evidences that downregulated
the four miRNA machinery components may play
an important role in breast pathobiology and that DGCR8 and
AGO2 might be associated with important clinical factors.
Keywords microRNAbiogenesis .DGCR8 . AGO2 .
Ki-67 . Invasive breast carcinoma
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