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Primary Thyroid Marginal Zone B-Cell Lymphoma of the Mucosa-Associated Lymphoid Tissue Type: Clinical Manifestation and Outcome of Rare Diasease - Consortium for Improving Survival of Lymphoma Study

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Author(s)
도영록
Alternative Author(s)
Do, Young Rok
Publication Year
2012
Abstract
Purpose: Primary thyroid marginal zone B-cell lymphoma of
the mucosa-associated lymphoid tissue type (pTY-MZL) is an
extremely uncommon form of lymphoma. Due to its rarity,
the natural history and optimal treatment modality for this
disease have yet to be clearly established. Methods: A total
of 27 patients with histologically confirmed pTY-MZL were
retrospectively analyzed. Results: The median age of our
subjects was 53 years (range 25–82). This study involved 17
females (63.0%) and 10 males (37.0%). Twenty-four out of 27
patients (88.9%) initially presented with localized disease,
defined by Ann Arbor stage I/II. Bone marrow involvement
was detected in 8.3% of the patients (2 patients), and 91.7%
of the patients (25 of 27) were categorized into the low or
low-intermediate risk group, according to the International
Prognostic Index criteria. Accompanying Hashimoto’s thy-roiditis was detected in 72% of the patients, whereas thyroglobulin
antibody levels were elevated in 70% of the patients.
Twenty-six patients were treated with surgery, radiotherapy
or chemotherapy, and 25 patients achieved complete
remission. During the follow-up period, only 2 patients
evidenced progression, and no deaths occurred over the
course of the study. Conclusion: pTY-MZL tends to be an indolent
disease. However, unlike other mucosa-associated
lymphoid tissue site MZLs, pTY-MZL was well controlled via
several treatment modalities, and the patients’ responses
were sustained for a prolonged period.
Copyright © 2011 S. Karger AG, Basel
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Acta Haematologica., Vol.127(2) : 100-104, 2012
Type
Article
ISSN
0001-5792
DOI
10.1159/000333113
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34846
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