A Co-Operative Study: Clinical Characteristics of 334 Korean Patients with
Moyamoya Disease Treated at Neurosurgical Institutes (1976-1994)
- Alternative Author(s)
- Yim, Man Bin
- Publication Year
- A co-operative study was conducted to determine the clinical
characteristics of patients with moyamoya disease who were diagnosed
and treated at neurosurgical institutes in Korea before 1995.
Twenty-six hospitals contributed 505 cases and among them, the
clinical characteristics of 334 patients with de®nite moyamoya disease
were evaluated. The number of patients began to increase from
the late 1980s, and after that approximately 20 patients were treated
each year. There were two age peaks: from six to 15 and from 31 to
40 years of age. Haemorrhagic manifestations occurred in approximately
43% of the patients. The major clinical manifestations were
haemorrhage in adults (62.4%) and ischaemia in children (61.2%).
Overall 54.5% of the patients experienced decreased consciousness
levels, mainly due to intracranial haemorrhage or cerebral infarction.
In the patients with ischemic manifestations, the adult patients
were more likely to have cerebral infarction than the pediatric
patients (80% vs. 39%) and the pediatric patients were more likely to
have TIA (61% vs. 25%). Thirty eight percent of the patients underwent
bypass surgery and 53% of these procedures were performed
bilaterally. Treatment policies, including indications for bypass surgery
and commonly used drugs, were somewhat di¨erent according
to the institution. Overall favorable outcome was 73%, and the most
signi®cant factor a¨ecting poor outcome was haemorrhagic manifestation.
This article describes the characteristics of 334 patients
with moyamoya disease, who were diagnosed and treated at neurosurgical
institutes in Korea before 1995.
Keywords: Moyamoya disease; Korea; co-operative study; clinical
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